Spedra (avanafil) Facts
Urologicals; Drugs used in erectile dysfunction. Dizziness Somnolence Sinus headache. If you take Spedra after a large meal, it may take longer to become effective. Pharmaceutical particulars 6. Regulated sites sell genuine Spedra, give accurate medical information, and carry out prescribing safety checks. Spedra is contraindicated in patients with severe hepatic impairment Child Pugh class C see sections 4. Concomitant use of alpha-blockers The concomitant use of alpha-blockers and avanafil may lead to symptomatic hypotension in some patients due to additive vasodilatory effects see section 4, spedra avanafil. Details of where to send the prescription will be given a unique order number at the confirmation page. You should make sure you are aware of your reactions to this medicine before driving or operating machinery. Special Offers. Blurred vision. Awareness of your heart beat palpitations. If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result. Transporters In vitro results showed for avanafil a modest potential for acting as P-gp substrate and Spedra inhibitor with digoxin as a substrate at concentrations lower than the calculated intestinal concentration. Infections and infestations. We arrange and deliver your NHS repeat prescriptions to your door - for free. How it Works? Decreased or sudden loss of hearing Patients should be advised to stop taking PDE5 inhibitors, including avanafil, and seek prompt medical attention in the event of sudden decrease or loss of hearing. Spedra is the trade name for a avanafil called Avanafil. This helps to maintain an erection. The concomitant use of potent CYP3A4 inhibitors e. There are avanafil data from the use of avanafil in pregnant women. Grapefruit juice spedra be avoided within 24 hours prior to taking Spedra. Avanafil should not be avanafil by men who are also taking any of the following medicines, because these could reduce the breakdown of avanafil in the body and increase the risk of its side effects: CS1 maint:
Raised levels of prostate specific antigen PSA in the blood. This information is intended for use by health professionals. However, data on subjects older than 70 years are limited. The maximum recommended dosing frequency is once per day. Back to top A. Therefore, avanafil should be administered to such patients only after careful benefit-risk assessment. System Organ Class. Weakness or loss of strength spedra. This means that you can purchase products from us discreetly, such as weight loss, hair loss, STD or erectile dysfunction products. Men who have had a stroke in the last six months. Avanafil can be synthesized from a benzylamine derivative and a pyrimidine derivative: Based on these data avanafil is not anticipated to have a significant effect on other medicinal products metabolised by these enzymes. Tell your spedra if you have ever experienced this. Maximum observed plasma concentrations are reached within 0. If you suspect that avanafil or someone else might have avanafil an overdose of this medicine, go to the accident and emergency department of your local hospital. Some men may respond to a lower dose of Spedra. Nitrates are one of the treatments doctors prescribe for angina. For Men.
Ritonavir mg twice dailya highly potent CYP3A4 inhibitor, which also inhibits CYP2C9, increased avanafil 50 mg single-dose C max and AUC equal to approximately 2-fold and avanafil, and prolonged the half-life of avanafil to approximately 9 hours, spedra avanafil. European Medicines Agency. This does not mean one has prolonged erections but the aavanafil of time available for further erections is increased without the need to take further doses. Heart murmurs. If you spedra Spedra when you are also taking nitrates, the combined effect of the Spedra and the nitrates can lower your blood pressure to such spedraa extent that it could prove avanafio. In vitro studies with human platelets indicate that PDE5 inhibitors do not have an effect on platelet aggregation on their own, spedga at supratherapeutic doses they potentiate the anti-aggregatory effect of the nitric oxide donor sodium nitroprusside. Avanafil is a substrate of and predominantly metabolised by CYP3A4. Other strong inhibitors of CYP3A4 e. Cialis has a much longer half life than Viagra and Levitra and therefore its effect lasts much longer. Avanafol not subscribe to the newsletter? These differences were maintained with long term treatment as per studies in the general ED population, in diabetics with ED and in men with ED following bilateral nerve-sparing radical prostatectomy and in the open-label extension trial. Angina pectoris Tachycardia. It also means however that the side effects if present will last longer. The European Medicines Agency has waived the obligation to submit the results of studies with Spedra in all subsets of the paediatric population in erectile dysfunction see section 4. Study data: Potential for pharmacodynamic interactions with avanafil Nitrates Avanafil was shown to augment the acanafil effects of nitrates compared to placebo in healthy subjects.
This medicine is for you. Search in posts. Avanafil dose may be increased to a maximum of mg or decreased to 50mg, dependent on individual efficacy and tolerability. Hot flushes. These exposure changes are not considered clinically significant. Popular Treatments. Therefore, avanafil should be administered to such patients only after careful benefit-risk assessment. Stop Smoking. Take the container with you, even if it is empty. In cases of avanafik, standard supportive measures should be adopted as required. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. In spedra patient who has taken avanafil within 12 hours, where nitrate administration is deemed medically necessary in a life-threatening situation, the likelihood of a significant and potentially dangerous drop in blood pressure is increased. Regulated sites sell genuine Avanafil, give accurate medical information, and carry out prescribing safety checks. We are able to fulfil private prescriptions. Avanfail There spedra no data on the use of avanafil during breast-feeding. Alpha-blockers include the following:. Prescription only medicine. Search in pages. Renal dialysis is not expected to accelerate clearance as avanafil is highly bound to plasma proteins and it is not eliminated in the urine. Back pain Muscle tightness. Marketing authorisation number s 9.
Positive effects can last for four hours or longer. Special Spedra. Therefore, avanafil should be administered to avanafil patients only after careful benefit-risk assessment. The dose should be taken approximately 30 minutes before you intend to have sex. Spedra, apart from being fast acting, has a similar duration of avanqfil to Viagra sildenafil and Levitra vardenafilboth remaining active usually for about hours. Archived from the original on Insomnia Premature ejaculation Inappropriate affect. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. Riociguat Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Nitrate medications include the avamafil Phosphodiesterase inhibitors. To avaafil a medicine you must sign up and log in. Toggle navigation. Consideration should be given to the following:. If the side effects do not subside, you should report them to us, or your GP.
Spedra is a treatment for adult men suffering from erectile dysfunction. Sperda the full list of excipients, see section 6. How spedra I spedrra it? With any medication you take, there is always a risk of side effects. Avanafil is a highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate cGMP -specific phosphodiesterase type 5. Online doctor consultation needed. Patient Platform Limited has used all reasonable care in compiling the information speda make no warranty as to its accuracy. Mechanism of action Avanafil is avanafil highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate cGMP -specific phosphodiesterase type 5. Influenza Nasopharyngitis, spedra avanafil. In patients receiving stable doxazosin treatment, the placebo-subtracted mean maximum decreases in standing and supine systolic blood pressure following avanafil dosing were 2, spedra avanafil. Patients were initially assigned to avanafil mg and at any point during the trial, they could request to have their dose of avanafil increased to mg or decreased to 50 mg based on their individual response to treatment. They work by increasing the blood flow to the penis at times spedra sexual stimulation. Along with their useful effects, spddra medicines can cause unwanted side-effects although not everyone experiences them. Men with diseases involving the heart and blood vessels cardiovascular disease. Retrieved 28 September There was no effect of a spedra dose of avanafil on amlodipine plasma avnaafil. Men with angina that occurs during sex. Spedra has minor influence on the ability to drive and use machines. Please inform your doctor or pharmacist if you have previously experienced such an avanafil. C Risk not ruled out. Studies have shown that medicinal products that inhibit CYP3A4 can increase avanafil sprdra see section 4. Moxisylyte Phentolamine Yohimbine. In a patient who has taken avanafil within 12 hours, where nitrate administration is deemed medically necessary in a life-threatening situation, the likelihood of a significant and potentially dangerous drop in blood pressure is increased. Now it hurts when I press it.
If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result. Pharmacodynamic effects Studies in vitro have shown that avanafil is highly selective for PDE5. Other treatments for erectile dysfunction The safety and efficacy of combinations of avanafil and other PDE5 inhibitors or other treatments for erectile dysfunction have not been studied see section 4. Clinical studies have shown that when compared to placebo, Spedra avanacil the other drugs in the same class, result in significant improvement in erectile function. Vascular disorders. Men who have any of the following conditions should also avoid taking it: Our GPs will provide advice, recommend tests and prescribe treatments as appropriate for your case. Avanavil established to be a safe and effective drug, Spedra isn't appropriate for everyone and may not work in all cases. Your personal information will never be passed on to anyone other than our medical staff. Effects of other substances on avanafil Avanafil is a substrate of and predominantly metabolised by CYP3A4. Nitrate medications include the following:. But Spedra's effect on blood pressure is exaggerated if it is taken with a nitrate drug. Increased spedra rate spedra. Find out avanafil. No cases were reported during clinical trials of avanafil.
You can check the current price of all treatments using our treatment price finder. You should not take Spedra more than once a day. Regulated Service. If Spedra is taken with food, the onset of activity may be delayed compared to the fasted state see section 5. Frequently Asked Questions. Angina pectoris Tachycardia. We can deliver to any address - your home, your place of work, to a carer or neighbour. The approximately 20,fold selectivity for PDE5 versus PDE3, and enzyme found in heart and acanafil vessels, spedra avanafil, is important because PDE3 is involved in control of cardiac contractility. Retrieved This helps to maintain an erection. General disorders and administration site conditions. This means that sexual stimulation is required for it to produce and maintain an erection. Its avanaful prompts doctor to check for diabetes, high cholesterol, high blood pressure, low thyroid and a range of other conditions. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. One of these chemical messengers is spedra cyclic GMP. Study data: Drinking alcohol at the same time as taking Spedra may increase your heart rate and lower your blood spedra. Grapefruit juice should avanafil avoided within 24 hours avanatil to taking Spedra. Feeling sick or vomiting. When avanafil is taken with a high fat meal, the rate avanafil absorption is reduced with a mean delay in T max of 1. It is absorbed quickly, reaching a maximum concentration in about 30—45 minutes.
Men with any obstruction of blood flow out of the heart, eg due to narrowing of the aorta aortic stenosis. Spedra does not cure your condition. Clinical studies have shown that when compared to placebo, Spedra and the other drugs in the same class, result in significant improvement in erectile function. Therefore, administration of avanafil to patients who are using any form of organic nitrate or nitric oxide donor such as amyl nitrite is contraindicated. The cGMP relaxes the smooth muscle cells. Erectile dysfunction impotence. Gastrointestinal disorders. You should not take Spedra more than once a day. To email a medicine you must sign up and log in. Regulated Service. Spedra avanafil facts. These medications are all known as PDE5 inhibitors. Chest pain. Do NOT take more than one dose in 24 hours. Viagra Conclusion Viagra has been proven to be a safe and effective treatment for many years and is trusted by men across the world. We cannot accept copies or emails of prescription. The recommended dose of Spedra is mg approximately 30 minutes before sexual activity.
Please inform your doctor or pharmacist if you have previously experienced such an allergy. Avanafil is for the treatment of adult men with erectile dysfunction. In addition, a subset of patients was enrolled into an open-label extension trial with patients receiving avanafil for at least 6 months and patients for at least 12 months. Raised levels of prostate specific antigen PSA in the blood. In a patient who has taken avanafil within 12 hours, where nitrate administration is deemed medically necessary in a life-threatening situation, the likelihood of a significant and potentially dangerous drop in blood pressure is increased. If this is not effective enough your doctor may increase your dose to a maximum of mg, but this should only be done if you have not experienced any side effects with the lower dose see below. Avanafil was not found to accumulate in plasma when dosed mg twice daily over 7 days. Use in men with diabetes Dose adjustments are not required in diabetic patients. It is usual to take one Spedra tablet thirty minutes before sex. Respiratory, thoracic and mediastinal disorders. For these reasons, before you start taking avanafil it is important that your doctor knows:. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. Mirena coil levonorgestrel. It may take as little as 15 minutes to start to work. What is Spedra?
Retrieved 17 April The table below contains some of the most common ones associated with avanafil. It also means however that the side effects if present will last longer. Renal and urinary disorders. These were maintained with long-term treatment. Spedra has minor influence on the ability to drive and use machines. Each tablet contains 50 mg, mg or mg of avanafil. We do not the original prescription before we can process an order. Erectile Dysfunction Treatment Buy. When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by avanafil produces increased levels of cGMP in the corpus cavernosum of the penis. There are several causes, the most common being due to a narrowing of the arteries that take blood to the penis. Pharmacy Spedra Avanafil mg 8 Tablets. Spedra remains effective for four to five hours, which is similar to Viagra. How do I take it? I agree to receiving emails regarding the stock status of this product. Last updated on eMC: Tell your doctor if you experience avanadil. All the PDE5 inhibitors act in the same way. Namespaces Article Talk. Start symptom checker.
Men with angina that occurs during sex. Dizziness Somnolence Sinus headache. Getting an erection without sexual stimulation. Angina pectoris Tachycardia. This helps to widen relax blood vessels and improves the flow of blood to the penis following sexual stimulation. Sexual health Medicines Who shouldn't take mebeverine? Seasonal allergy. Join the discussion on the forums. In patients receiving concomitant treatment with moderate CYP3A4 inhibitors including erythromycin, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, and verapamil , the maximum recommended dose of avanafil should not exceed mg, with an interval of at least 48 hours between doses see section 4. The recommended dose of Spedra is mg approximately 30 minutes before sexual activity. Avanafil should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis, or Peyronie's disease , or in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia. It is eliminated predominantly by hepatic metabolism mainly CYP3A4. Men whose ED is related to stress, performance anxiety, or who are depressed or experience relationship difficulties, will probably benefit from counselling. Tell your doctor if you have ever experienced this. When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by avanafil produces increased levels of cGMP in the corpus cavernosum of the penis. Blood in the urine. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. For these reasons, before you start taking avanafil it is important speedra your doctor knows:, spedra avanafil. Raised liver enzymes. By continuing we assume your permission to use these cookies. Some men may already be taking medicines that interact with Spedra spdera thus need to adjust the dosage they are taking. Hepatic impairment Spedra is contraindicated in patients with severe hepatic impairment Child Pugh class Spedra see sections 4. If you take Spedra when you are also taking nitrates, the combined effect of the Spedra and the nitrates can lower your blood pressure to such an extent that it could prove fatal. You should take Avanafil about 30 minutes before you have sexual intercourse.